Transient neonatal hyperthyrotrophinaemia: a serum abnormality due to transplacentally acquired antibody to thyroid stimulating hormone.

Transient neonatal hyperthyrotrophinaemia: a serum abnormality due to transplacentally acquired antibody to thyroid stimulating hormone.

In a screening programme for neonatal hypothyroidism an otherwise healthy female infant was found to have a high concentration of thyroid stimulating hormone in a filter paper blood spot and in serum. A high concentration was also found in the maternal serum. Mother and baby were both biochemically euthyroid with normal serum thyroxine concentrations. The apparently high concentration of thyroi...

Transient congenital hypothyroidism due to thyroid-stimulating hormone receptor blocking antibodies: a case series.

We describe seven infants with transient congenital hypothyroidism (CH) due to maternal thyroid-stimulating hormone receptor (TSH-R) blocking antibodies (TRAb) identified over three decades of newborn screening for CH in Wales, UK that represents a minimum incidence of 1.6% of CH cases. Infants with transient CH due to maternal TRAb presented with a spectrum of clinical and biochemical hypothyr...

Transplacentally acquired antibody to intrinsic factor with vitamin B12 deficiency.

ANTIBODY TO INTRINSIC FACTOR is found in the blood of about 60% of patients with pernicious anemia, and when present is considered pathognomonic of pernicious anemia, whether incipient or overt.”2 It is not clear whether the antibody has any etiological role in the disease or whether it is perhaps secondary to gastric injury, in which materials derived from gastric parietal cells are released i...

Case report: over-substitution of thyroxine due to interference in serum thyroid-stimulating hormone measurement.

A 70-year-old female patient underwent thyroidectomy and thyroablative radioiodine treatment for folliculary thyroid cancer with pulmonary metastases (pT1, NO, M1). For thyroid hormone replacement therapy, serum thyroid-stimulating hormone (TSH) concentrations were aimed to be below the lower limit of quantification of the assay (-0.03 mU/mL) with concentrations of free thyroxine and free triio...

Thyroid Stimulating Hormone Thyroid Stimulating Hormone